Study finds low-plastic diet eliminates plastic-associated chemicals in urine within 7 days

In a recent study published in the journal naturopathyResearchers characterized urinary levels of chemicals associated with plastics (Candidate PAC) in healthy adults.

Plastic is common in everyday life, which is harmful for us Candidate PAC. For example, bisphenols and phthalates are established endocrine disruptors. Exposure to bisphenols and phthalates leads to adverse health outcomes including metabolic syndrome and cardiovascular disease. Most studies are on their health effects Candidate PAC Observations have been limited, and only a few trials have examined whether modifying exposure routes could reduce urinary pac level.

Perth trial design and exposure assessment

In the current study, researchers described findings from the Plastic Exposure Reduction Transforms Health (PERTH) trial. They recruited 211 healthy adults (123 women and 88 men) in Australia for a longitudinal cohort study and included 60 of these subjects in a pilot randomized controlled trial (RCT). Nasal and urine samples were collected on non-consecutive days for both the group study and RCT.

Participants completed a comprehensive health examination including body composition, physiological and biochemical measures. All team participants had at least six Candidate PAC in urine samples on any given day. Mono-methyl phthalate and bisphenol A AP were found in <40% of participants. Bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) were found in 61.8% and 30.6% of nasal samples.

Other than this, pac Exposure Questionnaire, 24-hour personal care product (pcp) recall questionnaire to assess dietary intake, and the 24-hour dietary recall-plastic exposure questionnaire were administered. pac Inhalation, dermal absorption, and ingestion. The single-exposure model showed that each additional serving of vegetables and fruits was associated with a 1.82% reduction in mono-iso-butyl phthalate (MIBP) and a 6.99% increase in bisphenol S (BP) in urine.

In multiple-exposure models, higher intake of vegetables and fruits was associated with increased urine output BPWhile higher consumption of oils and fats was associated with less urine BP. Next, the team calculated total dietary plastic (TDP) score to estimate the number of plastic touchpoints of foods and beverages. average TDP The score was 41.6 per day, with women eating more foods in plastic packaging than men.

Dietary sources, personal care products, and body composition findings

increase in each unit TDP SCORE was associated with an approximately 0.09% increase in urinary mono(2-ethyl 5-hydroxyhexyl) phthalate. Similarly, urine BPA There was a 14.3% increase for each additional canned item consumed. In addition, increased use of pcps, such as hair, makeup, and skin products, were associated with higher levels of low-molecular-weight phthalates in urine, including mono(3-carboxypropyl) phthalate (mcpp) and mono-ethyl phthalate (MEP).

Among body composition parameters, higher fat was associated with less urine output. pacS; one standard deviation (sd) high body mass index (bmi) was associated with 16.3% less monopropyl phthalate (MBZP), while a sd Higher waist circumference was associated with a 22% lower mcpp. Cross-sectional associations were also observed between increased urine levels DEHP Metabolites and cardiometabolic biomarker levels in this healthy group.

For example, high urinary levels of mono(2-ethyl-5-oxohexyl) phthalate were associated with a 30.5% reduction in lipoprotein(a) and a 24.7% reduction in high-sensitivity C-reactive protein (HSCRP). Similarly, higher mcpp levels were associated with lower fasting serum glucose levels, without establishing higher pac Exposure is beneficial. in a seven-day pilot RCTParticipants were randomized into one of five groups.

Low-Plastic Interference Test Results

Group 1, i.e., low-plastic foods with minimal plastic touchpoints in production, processing, packaging, storage and preparation, reduced in urine MBZP Up to 46.7%, Mono-N-Butyl Phthalate (mnbp) compared to control 31.5% and bisphenol 58.5% (group 5; no intervention). Furthermore, the low-plastic foods and plastic-free kitchenware intervention (Group 2) resulted in greater reductions in urine output. MBZP, mnbpAnd BPA compared to control. one less plastic pcp Intervention (group 3) reduced urine output only mnbp By 35.3% relative to the control.

Specifically, Group 4, which included low-plastic foods, plastic-free kitchenware, and low-plastic pcpS, the greatest decrease in urine was mnbp (-44.1%) compared to controls. Replacing foods and beverages with less plastic alternatives had no effect on average daily energy intake in Groups 1, 2, or 4 or saturated fat intake in Groups 2 or 4. No adverse events or safety concerns were reported during this period. RCT.

Implications of reducing plastic exposure

in amount, pac Exposure was ubiquitous in healthy adults, with packaged, processed, and canned foods contributing to exposure. in the short term RCTReplacing diets with low-plastic alternatives, with or without plastic pcps and/or plastic-free utensils, was associated with significant reductions in urinary bisphenol A, MBZPAnd mnbp. More research is needed to examine the causal relationships between pac Exposure and its effects on human health and whether reducing exposure improves long-term health outcomes.